I’m not sure you could use a rust - python combo at this stage as holochain is actually targeting wasm and I think this could be a bit tricky to work with pythons interpreter / GC.
You really don’t need to know that much Rust to start making holochain apps. Most of you development will go into your front end and the type of Rust that developers need to know to use the HDK is pretty basic.
Also you will find Rust actually has a lot in common with python it terms of language design.
The big differences are you have to use types and there’s a borrow checker instead of a garbage collector.
This isn’t super accurate but you could think of the borrow checker as a garbage collector that runs when you compile.
As for types there’s a bit to learn but it allows you to be a bit more confident your programs will be correct at runtime which is pretty useful for writing this type of software.
You could write most of your software in Python and then setup a websocket connection to the hApp.
It really depends what your intentions are. If you are just looking to have a play and learn I’d encourage you to build something in Python because you are comfortable with it and then talk to the Rust backend over websocket.
Please feel free to ask me for help with any of this. I have a bit of modest Python experience and plenty of Rust experience. I think it would be cool to see this use case.